Chronic Pain JHS/EDS: Bibliography

Joint hypermobility  

Castori, M. (2012). Ehlers-danlos syndrome, hypermobility type: an underdiagnosed hereditary connective tissue disorder with mucocutaneous, articular, and systemic manifestations. ISRN Dermatology, 2012, 751768. doi:10.5402/2012/751768

Murray, K. J. (2006). Hypermobility disorders in children and adolescents. Best Practice & Research. Clinical Rheumatology, 20(2), 329–51. doi:10.1016/j.berh.2005.12.003

Shirley, E. D., Demaio, M., & Bodurtha, J. (2012). Ehlers-danlos syndrome in orthopaedics: etiology, diagnosis, and treatment implications. Sports Health, 4(5), 394–403. doi:10.1177/1941738112452385

Armon, K. (2015). Musculoskeletal pain and hypermobility in children and young people: is it benign joint hypermobility syndrome? Archives of Disease in Childhood, 100(1), 2–3.

Castori, M., et al  (2015). Spectrum of mucocutaneous manifestations in 277 patients with joint hypermobility syndrome/Ehlers-Danlos syndrome, hypermobility type. American Journal of Medical Genetics. Part C, Seminars in Medical Genetics, 11, 1–11. 

Castori, al  (2015). Connective tissue, Ehlers-Danlos syndrome(s), and head and cervical pain. American Journal of Medical Genetics. Part C, Seminars in Medical Genetics, 14, 1–14. 

Pacey, V., Tofts, L., Wesley, A., Collins, F., & Singh-Grewal, D. (2014). Joint hypermobility syndrome: A review for clinicians. Journal of Paediatrics and Child Health, 1–8.

Pacey, V., Adams, R. D., Tofts, L., Munns, C. F., & Nicholson, L. L. (2014). Proprioceptive acuity into knee hypermobile range in children with joint hypermobility syndrome. Pediatric Rheumatology Online Journal, 12, 40.

Pacey, V., Adams, R. D., Tofts, L., Munns, C. F., & Nicholson, L. L. (2015). Joint hypermobility syndrome subclassification in paediatrics: a factor analytic approach. Archives of Disease in Childhood, 100(1), 8–13. doi:10.1136/archdischild-2013-305304

​Tofts, L. J., Elliott, E. J., Munns, C., Pacey, V., & Sillence, D. O. (2009). The differential diagnosis of children with joint hypermobility: a review of the literature. Pediatric Rheumatology Online Journal, 7, 1. doi:10.1186/1546-0096-7-1

Shirley, E. D., Demaio, M., & Bodurtha, J. (2012). Ehlers-danlos syndrome in orthopaedics: etiology, diagnosis, and treatment implications. Sports Health, 4(5), 394–403. 

Chronic pain

Castori, M., Morlino, S., Celletti, C., Celli, M., Morrone, A., Colombi, M., … Grammatico, P. (2012). Management of pain and fatigue in the joint hypermobility syndrome (a.k.a. Ehlers-Danlos syndrome, hypermobility type): principles and proposal for a multidisciplinary approach. American Journal of Medical Genetics. Part A, 158A(8), 2055–70. doi:10.1002/ajmg.a.35483

Hoffart, C. M., & Wallace, D. P. (2014). Amplified pain syndromes in children: treatment and new insights into disease pathogenesis. Current Opinion in Rheumatology, 26(5), 592–603. doi:10.1097/BOR.0000000000000097

Clinch, J., & Eccleston, C. (2009). Chronic musculoskeletal pain in children: assessment and management. Rheumatology (Oxford, England), 48(5), 466–74. 

Rajapakse, D., Liossi, C., & Howard, R. F. (2014). Presentation and management of chronic pain. Archives of Disease in Childhood, 99(5), 474–80. 

Rombaut, L et al  (2014). Chronic pain in patients with the hypermobility type of Ehlers-Danlos syndrome: evidence for generalized hyperalgesia. Clinical Rheumatology. 

Walker, S. M. (2014). Overview of neurodevelopment and pain research, possible treatment targets. Best Practice & Research. Clinical Rheumatology, 28(2), 213–28. 


Rombaut, L., Scheper, M., De Wandele, I., De Vries, J., Meeus, M., Malfait, F., … Calders, P. (2014). Chronic pain in patients with the hypermobility type of Ehlers-Danlos syndrome: evidence for generalized hyperalgesia. Clinical Rheumatology. doi:10.1007/s10067-014-2499-0

Chronic fatigue

Staud, R., Mokthech, M., Price, D. D., & Robinson, M. E. (2015). Evidence for Sensitized Fatigue Pathways in Patients with Chronic Fatigue Syndrome. Pain. doi:10.1097/j.pain.0000000000000110

Voermans, N. C., Knoop, H., van de Kamp, N., Hamel, B. C., Bleijenberg, G., & van Engelen, B. G. (2010). Fatigue is a frequent and clinically relevant problem in Ehlers-Danlos Syndrome. Seminars in Arthritis and Rheumatism, 40(3), 267–74. doi:10.1016/j.semarthrit.2009.08.003

Autonomic dysregulation

De Wandele, I., Calders, P., Peersman, W., Rimbaut, S., De Backer, T., Malfait, F., … Rombaut, L. (2014). Autonomic symptom burden in the hypermobility type of Ehlers-Danlos syndrome: a comparative study with two other EDS types, fibromyalgia, and healthy controls. Seminars in Arthritis and Rheumatism, 44(3), 353–61. doi:10.1016/j.semarthrit.2014.05.013

Exercise interventions for pain and fatigue

Van Cauwenbergh, D., De Kooning, M., Ickmans, K., & Nijs, J. (2012). How to exercise people with chronic fatigue syndrome: evidence-based practice guidelines. European Journal of Clinical Investigation, 42(10), 1136–44. doi:10.1111/j.1365-2362.2012.02701.x

Stephens, S., Feldman, B. M., Bradley, N., Schneiderman, J., Wright, V., Singh-Grewal, D., … Tse, S. M. L. (2008). Feasibility and effectiveness of an aerobic exercise program in children with fibromyalgia: results of a randomized controlled pilot trial. Arthritis and Rheumatism, 59(10), 1399–406. doi:10.1002/art.24115

Hinton RY. (1986) Case study: rehabilitation of multiple joint instability associated with ehlers- danlos syndrome. J Orthop Sports Phys Ther. 8(4):193-8.

Møller, M. B. (2014). Functional adaptation of tendon and skeletal muscle to resistance training in three patients with genetically verified classic Ehlers Danlos Syndrome Corresponding author :, 4(3), 315–323.

Hanewinkel-van Kleef, Y. B., Helders, P. J. M., Takken, T., & Engelbert, R. H. (2009). Motor performance in children with generalized hypermobility: the influence of muscle strength and exercise capacity. Pediatric Physical Therapy : The Official Publication of the Section on Pediatrics of the American Physical Therapy Association, 21(2), 194–200. doi:10.1097/PEP.0b013e3181a3ac5f

Kemp S, RobertsI, Gamble C, Wilkinson S, Davidson JE, Baildam EM, et al. (2010) A randomized comparative trial of generalized vs targeted physiotherapy in the management of childhood hypermobility. Rheumatology 49:315–25.